Biomarkers discovered by Pure MHC represent nature’s own means of marking diseased cells for elimination, and our targets can be used with multiple immunotherapeutic approaches or modalities to achieve therapeutic effect, including TCR, CAR-T, bispecific antibodies, t-cell eliciting vaccines, antibody drug conjugates, etc.
Pure MHC has the ability to discover novel epitopes and validate “usual suspect” epitope targets such as NY-ESO-1/gp100/MART/MAGE that are presented by HLA on the diseased cell or primary tissue of interest, thus identifying viable targets that can distinguish affected versus healthy cells/tissue.
In addition, Pure MHC and can identify HLA immune targets directly from tumor tissue and from the blood. Thus, Pure MHC uses both in vitro and in vivo immune target discovery systems.
Pure MHC’s epitope discovery technology is the only technology that can identify peptide epitopes that are both: 1) unique to or upregulated in the affected state, and 2) compared to and validated as ligands presented by HLA molecules on primary tissues of interest.